Numerous epidemiologic studies suggest theaflavins in black tea can inhibit carcinogeneses. Recent research indicates that theaflavins can influence gene expression to modulate the process of carcinogenesis through the regulation of apoptosis. In the case of colon cancer cells, theaflavins can cause colon cancer cells to “commit suicide” (apoptosis).

There are multiple potential mechanisms by which theaflavins elicit their inhibitory effects against carcinogenesis:

·

Antioxidative effects

· Antimutagenic effects
· Anti-proliferation effects
· Inhibition of cell growth and apoptosis-inducing activity
· Inhibition tumor promotion-related enzymes
· Modulation of signal transduction pathways

References:

Jiebo Lu, Chi-Tang Ho, Geetha Ghai, and Kuang Yu Chen: Differential Effects of Theaflavin Monogallates on Cell Growth, Apoptosis, and Cox-2 Gene Expression in Cancerous versus Normal Cells1. Cancer Research 2000; 60: 6465-6471

Patel R, Ingle A, Maru GB: Polymeric black tea polyphenols inhibit 1,2-dimethylhydrazine induced colorectal carcinogenesis by inhibiting cell proliferation via Wnt/beta-catenin pathway. Toxicology Applied Pharmacology 2008; 227(1): 136-146

Halder B, Bhattacharya U, Mukhopadhyay S, Giri AK: Molecular mechanism of black tea polyphenols induced apoptosis in human skin cancer cells: involvement of Bax translocation and mitochondria mediated death cascade. Carcinogenesis 2007; 29(1): 129-138

Kaur S, Greaves P, Cooke DN, Edwards R, Steward WP, Gescher AJ, Marczylo TH: Breast cancer prevention by green tea catechins and black tea theaflavins in the C3(1) SV40 T,t antigen transgenic mouse model is accompanied by increased apoptosis and a decrease in oxidative DNA adducts. Journal Agricultural Food Chem 2007; 55(9): 3378-3385

Banerjee S, Manna S, Mukherjee S, Pal D, Panda CK, Das S: Black tea polyphenols restrict benzopyrene-induced mouse lung cancer progression through inhibition of Cox-2 and induction of caspase-3 expression. Asian Pacific Journal of Cancer Prevention 2006; 7(4): 661-666

Friedman M, Mackey BE, Kim HJ, Lee IS, Lee KR, Lee SU, Kozukue E, Kozukue N: Structure-activity relationships of tea compounds against human cancer cells. Journal of Agricultural and Food Chemistry 2007; 55(2): 243-253

Saha P, Banerjee S, Ganguly C, Manna S, Panda CK, Das S: Black tea extract can modulate protein expression of H-ras, c-Myc, p53, and Bcl-2 genes during pulmonary hyperplasia, dysplasia, and carcinoma in situ. Journal of Environmental Pathology, Toxicology and Oncology 2005; 24(3): 211-224

   
 
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