See also: ·ACC Abstract: Cholesterol-Lowering Effect of a Theaflavin-Enriched Green Tea Extract
·The Archives of Internal Medicine Article

The first randomized, placebo-controlled parallel study of theaflavins on lipid levels of individuals with hypercholesterolemia was performed by Nashai Biotech LLC.

The hypothesis was that theaflavins not only significantly lower LDL cholesterol, the “bad cholesterol”, in adults with high LDL cholesterol, but is free of side effects.  Although further research is needed to fully elucidate the mechanisms of action of theaflavins in lowering LDL, the outcomes of the study substantiated the hypothesis.

Choleve(the source of concentrated theaflavin)in  capsule form as well as a placebo  capsule were administered in exactly the same fashion to separate groups and were tracked using the same testing and the same indicators.  Study participants that received theaflavins capsules (Choleve) compared to those who took placebos showed 11.3 percent decreased serum total cholesterol and 16.4 percent reduced serum LDL-C, the bad cholesterol.

Comparing the two test groups mean percentage change in the following areas, the theaflavins group’s mean levels of TC, TG, HDL and LDL changed by 11.3 percent, 2.6 percent, 23 percent, and 16.4 percent respectively.  The placebo group’s mean levels of TC, TG, HDL and LDL changed by 0.7 percent, 5.6 percent, 0.7 percent, and 0.26 percent.

Table 2 Mean percent Change (X±SE) from Baseline in Lipid
Parameters in the study of theaflavins on hypercholesterolemia
  4 weeks 12 weeks
  Theaflavins(n=114) Placebo(n=109) Theaflavins(n=114) Placebo(n=106)
TC(%) -6.70±84 0.05±87 -11.34±89 -0.72±77
LDL-c (%) -9.58±09 1.75±29 -16.40±10 0.26±24
HDL-c (%) 0.35±10 -0.36±65 2.30±06 -0.69±59
TG (%) 0.51±58 11.79±82 2.58±52 5.58±76
Other recent observations indicate that intragastric administration of black tea inhibits platelet aggregation and prevents experimental coronary thrombosis in dogs, hence providing further indication that Black Tea prevents cardiovascular diseases.


Stangl V, Dreger H, Stangl K, Lorenz M:Molecular targets of tea polyphenols in the cardiovascular system.Cardiovascular Research 2007; 73(2): 348-358

Maron DJ, Lu GP, Cai NS, Wu ZG, Li YH, Chen H, Zhu JQ, Jin XJ, Wouters BC and Zhao J:Cholesterol-Lowering Effect of a Theaflavin-Enriched Green Tea Extract, A Randomized Controlled Trial.Archives of Internal Medicine 2003; 163:1448-1453

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